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Clips from Pure Genius - A Bunker Hill Christmas (S01E01)

"♪ If your head is aching ♪"
Pure Genius
"♪ I'll make it better ♪"
Pure Genius
"♪ 'Cause I ♪"
Pure Genius
"♪ Love the way ♪"
Pure Genius
"♪ You call me baby ♪"
Pure Genius
"♪ And you take me the way I am ♪"
Pure Genius
"Oh, wow."
Pure Genius
"Okay, this takes me back to the old days."
Pure Genius
"Does it kind of remind you of the office they gave me"
Pure Genius
"when I was a surgical intern at the Cleveland Clinic?"
Pure Genius
"Mm-hmm. I remember"
Pure Genius
"showing up at midnight, because if I didn't"
Pure Genius
"I would never get to see you."
Pure Genius
"If I recall, some of those visits"
Pure Genius
"I think I figured out how..."
Pure Genius
"(laughs)"
Pure Genius
"I am so sorry. I'll come back."
Pure Genius
"No, it's okay. This is my wife, Julianna."
Pure Genius
"Jules, this is Dr. Channarayapatra,"
Pure Genius
"- my, um, office mate. - (door closes)"
Pure Genius
"Oh. Uh, Dr...?"
Pure Genius
"Channarayapatra. Oh, it's-it's..."
Pure Genius
"it's wonderful to meet you."
Pure Genius
"I have heard so much about you and the kids."
Pure Genius
"Oh, thank you."
Pure Genius
"I will leave you two, to, uh..."
Pure Genius
"(laughing): Find me later."
Pure Genius
"Please, this is your office; it's... well,"
Pure Genius
"it's both of your offices, right?"
Pure Genius
"So, please, go ahead."
Pure Genius
"Okay."
Pure Genius
"I was just thinking,"
Pure Genius
"maybe we don't actually need to find a new way"
Pure Genius
"of imaging the brain. We need a new way"
Pure Genius
"to process the data we've already gotten from the brain."
Pure Genius
"the fMRI, which localizes brain functions and laid it..."
Pure Genius
"Laid it over the EEG,"
Pure Genius
"which would give us a picture of the seizure activity."
Pure Genius
"That should point us to the right area of the brain."
Pure Genius
"Exactly. And if we merged that composite image"
Pure Genius
"with the Diffusion Tensor MRI,"
Pure Genius
"we should be able to follow the neural pathway"
Pure Genius
"back to the seizure focus."
Pure Genius
"BOTH: Then we could see the seizure manifest"
Pure Genius
"itself in real time in three dimensions."
Pure Genius
"This is brilliant."
Pure Genius
"CHANNARAYAPATRA: I'll talk to James."
Pure Genius
"He could do it in his sleep."
Pure Genius
"- It's great to meet you. - Oh, you, too."
Pure Genius
"Just... just tell us if it isn't working."
Pure Genius
"We can handle bad news."
Pure Genius
"It's good news."
Pure Genius
"Wait. It is? Really?"
Pure Genius
"In fact, it's looking a little bit like a Christmas miracle."
Pure Genius
"(laughing): Oh, my God."
Pure Genius
"Her numbers improved?"
Pure Genius
"These are your latest numbers."
Pure Genius
"Your white cell count is 11,000."
Pure Genius
"11,000?"
Pure Genius
"- Are you serious? (laughing) - Oh, my God."
Pure Genius
"I was at 45,000."
Pure Genius
"Nothing we've done has ever brought"
Pure Genius
"than anything we could have ever imagined."
Pure Genius
"Oh, my God."
Pure Genius
"See?"
Pure Genius
"(laughing): I mean, you're my good luck charm."
Pure Genius
"(laughing): No, I'm not."
Pure Genius
"(laughter)"
Pure Genius
"Oh, baby."
Pure Genius
"You guys are the best."
Pure Genius
"Uh, James."
Pure Genius
"Uh, not to get ahead of ourselves,"
Pure Genius
"but there's a concert coming up in a couple of weeks,"
Pure Genius
"Phillip Phillips is playing."
Pure Genius
"He's been a huge hero to Maddie throughout all of this."
Pure Genius
"I want to buy tickets,"
Pure Genius
"but I need to know if there's any way you think"
Pure Genius
"she's gonna be strong enough to go."
Pure Genius
"Let me."
Pure Genius
"(chuckles)"
Pure Genius
"(exhales)"
Pure Genius
"I hear the FDA is here to rule on the treatment"
Pure Genius
"- for GSS. - Yes."
Pure Genius
"What are the chances of getting approved?"
Pure Genius
"I feel our chances are sky-high, Louis."
Pure Genius
"(laughing)"
Pure Genius
"Bishop to queen's rook five."
Pure Genius
"(Louis laughing)"
Pure Genius
"Louis, the bishop doesn't move that way."
Pure Genius
"It moves diagonally."
Pure Genius
"GSS is caused by abnormally folded proteins"
Pure Genius
"These prions stick together in clusters"
Pure Genius
"called oligomeric aggregates,"
Pure Genius
"We've been working on a new medication"
Pure Genius
"called PAI 120b."
Pure Genius
"It's a prion aggregate inhibitor."
Pure Genius
"This drug sticks to these abnormal prion proteins"
Pure Genius
"so they can't clump together in these toxic aggregates."
Pure Genius
"CHENG: We've been producing it right here"
Pure Genius
"in our pharmacologic sciences lab."
Pure Genius
"It's in compliance with all FDA standards."
Pure Genius
"This disease is attacking his body and his mind,"
Pure Genius
"and before long,"
Pure Genius
"even his shadow of an existence will come to an end."
Pure Genius
"But our drug has a chance to change all that."
Pure Genius
"Worst case scenario, this is a huge leap"
Pure Genius
"towards curing this insidious illness."
Pure Genius
"we give a man his life back."
Pure Genius
"I-I mean, this is just a remarkable presentation."
Pure Genius
"It-it's one of the strongest applications"
Pure Genius
"I've seen for a Phase One Clinical Drug trial."
Pure Genius
"BELL: Great. So we can move towards human trials."
Pure Genius
"But it's not ready yet."
Pure Genius
"You have eight weeks of safety data in your animal models,"
Pure Genius
"and I totally agree the numbers are really promising,"
Pure Genius
"but, James, that's only eight weeks."
Pure Genius
"I'm sorry."
Pure Genius
"I need more data from the animal models"
Pure Genius
"You're looking at six to 12 months, at least."
Pure Genius
"♪ ♪"
Pure Genius
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