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Clips from Pure Genius - Around the World in Eight Kidneys (S01E01)

"- James. - Hey."
Pure Genius
"CHENG: You're back."
Pure Genius
"How was your vacation?"
Pure Genius
"Lovely."
Pure Genius
"Uh, nice."
Pure Genius
"Yours?"
Pure Genius
"I had a good time. Yeah, good."
Pure Genius
"(sighs)"
Pure Genius
"WALLACE: Everything looks good, Constance."
Pure Genius
"You adapted to the new machine beautifully."
Pure Genius
"Another 24 hours of observation and we can let you go home."
Pure Genius
"Any questions?"
Pure Genius
"Uh, just the same one I've been asking all week."
Pure Genius
"That's the whole point of the trial; you get the Rolls-Royce"
Pure Genius
"of dialysis in the privacy of your own home."
Pure Genius
"I-I can't believe we're gonna get our freedom back."
Pure Genius
"Both of us."
Pure Genius
"Lauren, you have been my angel for two years,"
Pure Genius
"driving me to and from dialysis three days a week."
Pure Genius
"She never complained."
Pure Genius
"It hasn't been that bad, Mom."
Pure Genius
"Dr. Wallace knows..."
Pure Genius
"for the Paris Opera Ballet."
Pure Genius
"Isn't that one of the best companies in the world?"
Pure Genius
"The best."
Pure Genius
"Wow. And that's why"
Pure Genius
"this dialysis machine is a godsend."
Pure Genius
"I mean, it's... (exhales)"
Pure Genius
"it's gonna give me my independence back, and..."
Pure Genius
"Lauren can move to Paris and..."
Pure Genius
"(exhales) live her dream."
Pure Genius
"Whew."
Pure Genius
"Constance, are you..."
Pure Genius
"Yeah. Maybe. Just a little bit."
Pure Genius
"Blood pressure's fairly low."
Pure Genius
"I need to order an EKG and echocardiogram."
Pure Genius
"something wrong with your heart."
Pure Genius
"Constance Durand, our kidney patient,"
Pure Genius
"Heart failure? I thought she just needed dialysis."
Pure Genius
"It's called cardiorenal syndrome."
Pure Genius
"It's a known complication in dialysis patients."
Pure Genius
"to attack the heart."
Pure Genius
"The damage results in impaired cardiac function."
Pure Genius
"And the onset, it can be sudden."
Pure Genius
"Based on her echo,"
Pure Genius
"her left ventricular ejection fraction is 18%."
Pure Genius
"Yeah, her heart's barely pumping blood,"
Pure Genius
"which means she can't tolerate the lengthy dialysis."
Pure Genius
"Yeah, and her kidneys are shot. Patients like this don't live"
Pure Genius
"more than a few weeks without a new kidney."
Pure Genius
"What about a kidney transplant?"
Pure Genius
"Constance has a very rare tissue type."
Pure Genius
"Her CPRA is 89,"
Pure Genius
"which means she'll reject most kidneys donated"
Pure Genius
"through an organ network."
Pure Genius
"- What about her daughter? - Not a match."
Pure Genius
"What about a kidney paired donation?"
Pure Genius
"- What's that? - It allows donors"
Pure Genius
"who are incompatible with their loved ones"
Pure Genius
"to switch their kidneys with other donor/recipient pairs."
Pure Genius
"Yeah. Lauren would donate her kidney to a stranger,"
Pure Genius
"whose loved one would then donate their kidney"
Pure Genius
"to another stranger..."
Pure Genius
"The pattern would repeat itself"
Pure Genius
"until the chain circled back around"
Pure Genius
"and Constance would get a compatible kidney."
Pure Genius
"- Boom. Sounds great. Let's do that. - Yeah, but it's not"
Pure Genius
"gonna be easy building a chain around a sensitized patient"
Pure Genius
"- like Constance. - She's right. These chains are built"
Pure Genius
"using crude algorithms, designed for single transplant networks."
Pure Genius
"Which is why we're not gonna rely on"
Pure Genius
"someone else's algorithm; we're gonna build our own."
Pure Genius
"- Of course we are. - (chuckles)"
Pure Genius
"(trilling)"
Pure Genius
"So, what am I looking at?"
Pure Genius
"Each node represents a donor/recipient pair."
Pure Genius
"Constance and Lauren are the one in the middle."
Pure Genius
"- Do those lines indicate matches? - Mm-hmm. Yep."
Pure Genius
"So how long does it take to build a chain?"
Pure Genius
"I'm rendering the algorithm on 4,000 cloud computers,"
Pure Genius
"so what would take 36 hours should prob... Oh, it's done."
Pure Genius
"(keys clacking)"
Pure Genius
"(beeping)"
Pure Genius
"Damn it. No matches."
Pure Genius
"You know, Constance has a very interesting ethnic background."
Pure Genius
"She's part French and part Ashkenazi."
Pure Genius
"Tissue type is hereditary."
Pure Genius
"Patients of similar ethnicities"
Pure Genius
"are more likely to be a match."
Pure Genius
"We could target people in specific parts of the world..."
Pure Genius
"You want me to expand the algorithm internationally?"
Pure Genius
"Can it be done?"
Pure Genius
"Bonjour. I'd like to request access to your transplant database."
Pure Genius
"It's for a kidney paired donation."
Pure Genius
"In the U.S."
Pure Genius
"Sure, I'll hold."
Pure Genius
"Hola. Información del donantes de órganos."
Pure Genius
"Bunker Hill y James Bell. Sí. Gracias."
Pure Genius
"(speaking Mandarin)"
Pure Genius
"(speaking Hindi)"
Pure Genius
"I've already spoken to the embassy."
Pure Genius
"Yes, I know international organ donations are rare."
Pure Genius
"Guys, I think this is working."
Pure Genius
"(murmuring) We've got three pairs. Four."
Pure Genius
"BELL: Five. Six. Seven. Eight."
Pure Genius
"It's called a kidney paired donation."
Pure Genius
"seven other donor/recipient pairs from around the world."
Pure Genius
"We'd have 'em all fly here"
Pure Genius
"And this is the only way to save my mom?"
Pure Genius
"This is the only option I see."
Pure Genius
"(exhales) I'm sorry. This is a lot."
Pure Genius
"I... First, you tell me I'm dying,"
Pure Genius
"and now you're telling me that my daughter has"
Pure Genius
"to donate her own kidney to a stranger."
Pure Genius
"Yes."
Pure Genius
"But, in return,"
Pure Genius
"a stranger donates a kidney to you."
Pure Genius
"When would I be able to dance again?"
Pure Genius
"Your recovery would take... six to eight weeks."
Pure Genius
"Well, then her answer's no."
Pure Genius
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